Are there any antidepressants that have no side effects?

No antidepressant has a side effect profile that’s ideal for everyone however, side effects are not the reason you are taking an antidepressant. Every antidepressant has different effects, and the most important issue is whether the antidepressant will be effective at stopping your depression. You do not want to end up taking a medication with no side effects that does not stop your depression symptoms. If there are side effects, these usually occur within the first month or so after beginning or increasing the medication and tend to disappear over days to weeks.