Major depression can disrupt the normal functions of your body, causing decreased sexual interest and hormonal changes, as well as an increase in headaches, joint pain, muscle pain, stomachaches, and digestive problems. Major depression alters the biochemistry of your brain, and every episode of depression makes the illness worse. Your thoughts are slowed, your concentration is impaired, and intrusive thoughts come into your mind and repeat over and over.
Your mind is taken over by worries, self criticism, guilt, and thoughts of death. During an episode of major depression, your perception of the world is distorted. Good situations look worse than they are, and bad situations look hopeless. Wherever you look, there is no satisfaction and no peace from your dark, negative emotions and thoughts.