Is Norpramin an effective antidepressant?

Norpramin (generic name: desipramine) is one of the best antidepressants ever made. It helps the body strongly increase norepinephrine in the gaps between brain cells at low doses, and it has some effect on serotonin and dopamine at higher doses. Like other antidepressants, studies have shown that Norpramin can increase the brain cell-healing factor called BDNF.

Although it is not licensed for this use, Norpramin (as well as other medications that increase norepinephrine) is effective at preventing migraine headaches and the pain that arises from nerve damage in diabetes. It is often used to treat chronic pain in the neck; shoulders, and lower back. Norpramin works well for individuals who have severe pain on the soles of their feet from alcoholism.

Patients say that Norpramin reduces their darkest emotions; you can still feel their presence, but they are in the background and do not seem as painful. Norpramin helps keep patients from overthinking and making mountains out of molehills. It has a slight dulling effect on sadness, anger, anxiety, and other emotions. Norpramin produces fewer anticholinergic side effects (like daytime sleepiness, dry mouth, or constipation) than the other tricyclic antidepressants. Many people are happy taking Norpramin all their lives and prefer it to SSRIs and other more modern medications they have tried.

Norpramin comes in 10, 25, 75, 100, and 150-milligram tablets. It is usually started at 25-50 milligrams at bedtime and increased to 150-300 milligrams daily. After taking Norpramin, it will take about five hours to reach its peak concentration in your bloodstream. After reaching a steady level in the bloodstream, it takes about three days to leave the body.

Based on patients’ comments, Norpramin is one of the best antidepressants. Many depressed patients show their first response to treatment only after Norpramin is added. It may trigger mania in patients with bipolar disorder, so it should be avoided in patients with this illness.