Although it can be a big relief when your most painful depressive symptoms fade, the ultimate goal of treatment is to eliminate all your depressive symptoms. Surprisingly, it may not be easy to tell when your episode of unipolar major depression is finally over. If you have been depressed for a long time, you may make the mistake of thinking that some of your depressive symptoms are part of your nature and not the disease. Many of my patients have thought their depression was over, but when we increased their medications, they found that they had still been somewhat depressed. You need to persist aggressively in your treatment until you are sure you feel like your most normal and natural self.